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Abstract 564: An inflammatory diet and risk of Crohn’s disease and ulcerative colitis: A prospective cohort study
Chun-Han Lo, MD, postdoctoral research fellow, department of epidemiology, Harvard T.H. Chan School of Public Health, Cambridge, MA
Researchers collected data from 204,055 women and men, followed over 24-30 years, who participated in the Nurses’ Health Study, Nurses’ Health Study II and Health Professionals Follow-up Study. Dietary information was gathered using food questionnaires every four years. Researchers used the empirical dietary inflammatory pattern (EDIP) score to evaluate diets based on 18 food groups. Participants who had the highest EDIP score (more inflammatory diet) had a 45 percent increased risk of Crohn’s disease. Additionally, people who switched to a more inflammatory diet had an increase in risk of incident Crohn’s disease, suggesting a dynamic effect of diet on disease risk. However, the high inflammatory diet was not associated with risk of incident ulcerative colitis.
Abstract 404: Risk of post-colonoscopy irritable bowel syndrome in patients with and without antibiotic exposure
Ravy K. Vajravelu, MD, MSCE, instructor of medicine, division of gastroenterology; faculty fellow, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia
This retrospective cohort study analyzed more than 402,000 individuals age 50 and older enrolled in a database from 2000-2016 who underwent colonoscopy. Researchers sought to assess whether the bowel cleansing for colonoscopy in conjunction with antibiotic exposure within 14 days before or 14 days after the procedure resulted in the later diagnosis of irritable bowel syndrome (IBS) or IBS-related symptoms. The study found that antibiotic exposure within 14 days after a screening colonoscopy was associated with an increased likelihood of subsequent IBS diagnoses.