One Comment

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    Michael Mogadam, MD, FACP, FACG

    Human atherosclerosis, unlike germ-free mice atherosclerosis fed a particular diet with or without any Roseburia germs, develops over many decades. Autopsies of some newborn babies who’s died of various causes have shown very early development of plaque formation. Furthermore, there are at least 20 major risk factors for coronary artery disease in humans along with numerous minor risk factors plus over 200 “contributory” factors. So the microbiome of the gut may fall into perhaps the last or at best the second class of risk factors. It is important to recognize that short-term or even long-term alteration of gut microbiome is not going to change the major and minor coronary artery disease risk factors. Hence the findings of this study in mice is highly unlikely to become relevant to CAD.


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